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The current views ascribe fundamental function to chloroplasts in orchestrating defense responses: upon plasma membrane sensing biological threats, signals are quickly relayed to chloroplasts through the plasma membrane/chloroplast dual-located proteins or calcium signal 5,7

Melatonin reprograms the effector state of activated ILC2s To further dissect the effects we had observed, we isolated aILC2s from IL-33 challenged BALB/c mice ( Supplementary Figures 2 ) and performed bulk RNA sequencing, comparing the transcriptome of vehicle and melatonin treated cells ( Figure 5A )