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( B ) Under conditions of APAP overdose along with iron overload, the excessive cellular free iron reacts with mitochondrial reactive oxygen species (ROS) to induce lipid peroxidation (LPO) of membranes

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PeerJ 5:e3179v2 Wu Y, Han H, Qin J, Wang Y (2015) Replacement of fishmeal by soy protein concentrate with taurine supplementation in diets for golden pompano ( Trachinotus ovatus )

Notably, histological analysis at this time point revealed no significant hepatocyte damage, suggesting that the rapid decrease in hepsin protein levels may primarily result from the activation and subsequent degradation of the hepsin serine protease in response to APAP-induced hepatotoxicity