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Amylin and Cagrilintide activate CGRP-like neurons in the AP that project to: Nucleus tractus solitarius (NTS) , autonomic center Parabrachial nucleus , integration of taste and satiety Hypothalamic pathways , energy balance The result: strong central appetite suppression and stabilization of satiety between meals

This proposed connection to GILZ-mediated signalling could help explain DSIPs anti-inflammatory effects and its capacity to modulate immune function, though this remains a hypothesis under investigation

PMID: 95 BektasMPayneSGLiuHGoparajuSMilstienSSpiegelS