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As ionic strength increases (adding salts), this repulsion is shielded, which in some cases can lead to increased aggregation or precipitation of the peptide (especially if the peptide has hydrophobic patches)

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Similarly, non-pharmacological interventions such as plasma-activated medium therapy can induce LC cell death via ferroptosis pathways (76)

Male rats with PTSD-like behaviors showed elevated p -cresol (a neurotoxic metabolite linked to overgrowth of Ruminococcaceae and Lachnospiraceae ) in prefrontal cortex, leading to dopaminergic dysfunction with increased DA, increased dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), and significantly elevated DA D3 receptor expression compared to controls (Laudani et al., 2023)