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Advanced tools, including in vivo autophagy/mitophagy reporters, high-resolution mitochondrial imaging, and integrative multi-omics, are needed to resolve these discrepancies and identify key downstream mediators such as NLRP3, the Nur77-IDH1 axis, and regulators of ferroptosis and pyroptosis

Jimi E, Aoki K, Saito H, DAcquisto F, May MJ, Nakamura I, et al