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With advancing age, mitochondrial function deteriorates, characterized by increased ROS production, accumulation of mitochondrial DNA (mtDNA) mutations, altered mitochondrial dynamics, a decline in the mitochondrial unfolded protein response (UPRmt), and reduced respiratory chain activity (Sun et al., 2023) Additionally, AS-IV reduces ROS overproduction and mitochondrial dysfunction induced by angiotensin II (Ang II), thereby inhibiting vascular smooth muscle cell senescence (Lu Y

Oxidative stress assumes a critical role in AD and other dermatological conditions, evidenced by increased oxidative stress marker levels and diminished antioxidant levels in affected individuals ( S

This elevation of circulating 2MBC contributes to cardiovascular dysfunction, such as atherosclerosis, as a result of the activation of excessive platelet activation