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In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation

[PubMed] [Google Scholar] Sikiric, P

Preventing the development of arterial hypertension as a primary prevention method through lifestyle changes including diet and starting physical activity can significantly reduce the occurrence of cardiovascular diseases

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