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Results Drug-induced tendinopathy in spontaneous reporting systems First, we investigated the association between the use of a particular drug and the incidence of tendinopathy in FAERS, CVARD, and JADER using a disproportionality analysis by calculating each ROR and its Z score

In addition, when CNS insulin signaling is inhibited by antibodies to insulin or by inhibitors of insulin receptor signaling molecules, systemic insulin fails to suppress hepatic endogenous glucose production

This is a very important point

But it is worth being precise: these are proposed and studied mechanisms, not settled clinical facts