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This conjugate is then a substrate for a phase I type reaction, namely, hydrolysis to isonicotinic acid ( Figure 42 )

Dihexa works by binding to the HGF receptor c-Met on hippocampal neurons, activating intracellular signaling pathways that increase synaptogenesis, dendritic spine density, and NMDA receptor expression

Superoxide measurement Cells were grown in a 12 well plate to about 50% confluence after which the media were removed and the cells were washed with HBSS (Hanks Balanced Salt Solution) followed by a 1 h pretreatment with 25 M dihydroethidium (DHE), from Life Technologies

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