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(170), transplanting the fecal microbiota of MDD patients into sterile rats led to an increase in fecal SCFA levels when compared to controls and sodium butyrate improved depressed behavior in rats

In addition, nasal sprays provide specifically focused distribution into the nasal passages, where peptides can act systemically or locally

zero published human clinical trials as of this writing a 2021 peer-reviewed review states plainly that no NNMT-targeted clinical trials have been reported

This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging