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[21] clearly showed that at least -GST isoform is present, both inside the nucleus and in the outer nuclear membrane, suggesting that GST plays a major protective role in the nucleus against alkylating compounds and organic peroxides

These include the nitric oxide (NO) signaling system, angiogenic responses via VEGFR2, and antioxidant defense mechanisms involving HO-1 and other key enzymes (Jzwiak et al

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