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This remains an actively moving area, however: on February 27, 2026, the HHS Secretary publicly announced an intent to move roughly 14 of the 19 Category 2-listed peptides, reportedly including ipamorelin and CJC-1295, back toward Category 1 status, and multiple industry and legal-news outlets reported further FDA action in the following months easing Category 2-related restrictions on this group of peptides

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[24,59,60] hCDR1 also downregulated IL-1, IFN-, and TNF- in addition to IFN-, and upregulated the immunosuppressive cytokine transforming growth factor- (TGF-)