(4) Diseases: Chronic kidney disease, severe anemia, hypothyroidism, malignancy and drugs that affect the absorption of B vitamins and FA have been shown to increase Hcy level ( 4 Hcy and thyroid hormones Thyroid hormone (TH) is a major regulator of cellular metabolism and maintains metabolic homeostasis by coordinating networks of carbohydrate, lipid and protein metabolism
Post-traumatic stress disorder (PTSD) PTSD, arising from exposure to a traumatic event, is highly comorbid with SUDs, as individuals may use substances to numb intrusive thoughts, flashbacks, nightmares, or intense emotional distress associated with the trauma
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Findings on altered ACs levels in depression have recently emerged [29]