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Your doctor also will review your medical history for medical illnesses (diabetes, immune disorders) or surgeries, such as stomach removal, that can lead to B 12 deficiency

Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

Lycopene therapy in idiopathic male infertility--a preliminary report

Unlike a daily oral supplement, most people who need B12 injections get them once or twice a week or even every few weeks, says Foxx