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Despite the above claims, there are no clinical trials showing that coffee enemas can improve health

Deficiencies in these vitamins can lead to significant neurological and psychiatric conditions, including Wernicke Korsakoff syndrome, Parkinsons disease, and various mental illnesses

Because cellular iron output is mediated by FPN1 and polycupric ferrous oxide enzymes (such as ceruloplasmin), a decrease in the expression of FPN1 or ceruloplasmin can increase the sensitivity of cells to ferroptosis [29,30,31,32]