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The reality of oral administration for musculoskeletal indications is straightforward: the peptide disperses through the digestive system before it reaches the injury site, and what arrives at a tendon or joint after that journey is a fraction of what a subcutaneous injection placed near the tissue delivers

Nevertheless, as the dataset does not fully account for within-subject dependence, some degree of non-independence cannot be entirely ruled out

For practical accessibility, DSIP is currently more available but with weaker mechanistic understanding