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They include 'overactive' immune system disorders, which is when the bodys immune system attacks and destroys its own tissue, and 'underactive' system disorders, which is when the bodys defence against disease is reduced

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In the present study, we examined changes in glucose metabolism in a mouse systemically harboring a loss of function mutation in Insr (a single amino acid substitution from proline to leucine at 1195 amino acid residue (P1195L)), which has been shown to act as a dominant-negative mutant in heterozygosity 6