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As for the role that caffeine has in the purported benefits of the coffee enema, drinking coffee is a far more effective method for increasing the amount of caffeine in your blood (and hence causing vasodilation to potentially send toxins from the blood into the colon, or causing increased bile acid secretion to potentially facilitate liver detoxification) compared to administering it at the other end

10.1007/s00204-019-02409-6 2 AllamV.PatelV

(eds) Joint Function Preservation: a Focus on the Osteochondral Unit (Springer International Publishing, 2022)

From boosting immune function and detoxifying our bodies to protecting against chronic diseases and promoting skin health, glutathione proves to be an essential molecule for our optimal functioning