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Compounding pharmacies entered the GLP-1 market in 2022 when demand for semaglutide and tirzepatide outstripped supply and both drugs hit the FDA Drug Shortage List, thereby permitting compounders to produce copies at a fraction of brand-name prices

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IGF1R autophosphorylation also recruits Shc, which leads to Grb2/SOS/Ras activation and downstream ERK1/2 phosphorylation

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