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La toxicidad cutnea es menor que con otros frmacos similares, y se ha descrito algn caso aislado de erupcin cutnea inespecfica y dermatitis exfoliativa120, y tambin eritrodisestesia palmoplantar, xerosis y decoloracin de la piel121

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In this context, the use of probiotics, prebiotics, specific diets, dietary supplements, fecal microbiota transplantation, some pharmacological interventions, and improved sleep has been suggested