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Compounds showing 10-fold improvements in maze learning or complete reversal of cognitive deficits in mice consistently fail to demonstrate meaningful clinical benefit

Zouari M, Ahmed CB, Zorrig W, Elloumi N, Rabhi M, Delmail D, Abdallah FB (2016) Exogenous proline mediates alleviation of cadmium stress by promoting photosynthetic activity, water status and antioxidative enzymes activities of young date palm (Phoenix dactylifera L.)

Additionally, oxidative stress plays a key role in bone deterioration, causing inflammation, angiogenesis and synovial proliferation [16]

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