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2.3 Normal mode analysis (NMA) NMA was performed to characterize the inherent flexibility of MRP1 and MRP7 using DynaMut ( This extracts the atomic displacement of the C atoms and their relative motion amplitude in order to account for their intrinsic motions (Rodrigues et al., 2018)

Along with oxidative stress, these abnormal molecular changes lead to impaired mitochondrial respiratory function, ATP depletion, and various destructive cellular processes, such as mitochondrial fission, mitophagy, and programmed cell death, as we discuss below

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