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Frey II, a pioneer in intranasal central nervous system (CNS) delivery and adjunct professor at the University of Minnesota, explained it perfectly: We proved you could noninvasively deliver stem cells to the brain from the nose

They observed an increase in the frequency of both peripheral and central nervous system anti-inflammatory IL-10-secreting regulatory T cells (Treg cells) and, in parallel, a decrease of pro-inflammatory Th1 and Th17 responses (Benkhoucha et al., 2014)

Muller et al., 2018)

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