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However, supplements should support rather than replace healthy habits

Most human DSIP studies are more than 30 years old and were conducted before many modern clinical-trial standards became routine

During SARA, rapid microbial fermentation leads to the accumulation of lipopolysaccharide (LPS) and histamine, which downregulate tight junction proteins and increase epithelial permeability, thereby compromising the structural integrity of the ruminal epithelial barrier 52