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3.4 Disruption of folliculogenesis and oocyte function by the endometriotic microenvironment The endometriotic microenvironment is characterized by elevated levels of reactive oxygen species (ROS), iron overload, pro-inflammatory cytokines, and altered immune cell infiltration

5a), approved for the treatment of amyotrophic lateral sclerosis, increases ROS levels by multiple mechanisms, including decreasing LDH-A and NAD + levels to increase oxidative stress, as well as interfering with the xCT antiporter to block the cystineglutamate pump

In summary, this study provides strong evidence that hGMSCs possess both mesenchymal and neural differentiation potential, and that treatment with the Epitalon peptide significantly promotes neurogenic gene and protein expression