The expanded range of metabolic dysfunction in children with persistent frequent seizures is associated with developmental delay, and if surgical treatment is not available, medical treatment to control seizures may improve neurocognitive outcomes (116)
Angiogenesis: Stimulates blood vessel growth and tissue repair, including in aged animals (PubMed 15037013)
However, in clinical trials targeting severe cognitive impairment, chronic fatigue syndrome, or neuropathy, therapeutic doses usually range from 1,500 mg to 3,000 mg (1.5g 3g) daily
Moreover, PGC-1 activator ZLN005 mitigates renal injury by accelerating mitochondrial clearance in mice with cisplatin-induced AKI, increasing co-localization between LC3 and damaged mitochondria [51]