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[12] Oxidative-stress-associated diseases Glutathione depletion is documented across a wide range of conditions including liver disease, cystic fibrosis, sickle-cell anemia, HIV/AIDS, diabetes, cardiovascular disease, and neurodegeneration and glutathione status is considered a marker of oxidative stress in aging

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Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element