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Several distinct populations of microglia and macrophages have been described in the aging brain, including dark microglia (Bisht et al., 2016), IFN-responsive microglia (Kaya et al., 2022), and senescent-like microglia (Gross et al., 2025), underlying the heterogeneity of immune cell responses to aging-related stress

Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

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This action leads to a reduction in intracellular GSH levels, resulting in increased oxidative stress, which induces apoptosis and cell cycle arrest