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Patients in a sustained deficit (300500 calories below maintenance) typically lose 12 pounds during this window, though body composition changes aren't yet visible

And those nutrients are delivered in forms that can be used by the body

Interestingly, protein complexes that co-purify with activated integrin complexes contain microtubule-associated proteins, including EB1 and liprins, implicating activated integrins in the formation of CMSCs and PMAPs [59]