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In the context of viral replication, constraint-based modeling allows the simulation and prediction of the viral capacity to replicate within a host cell by considering nutrient availability, energy resources, and other cellular factors 16,17

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Besides cytokines, and vascular endothelial growth factor (VEGF), the local production of prostaglandin F2 (PG2 ) leading to vascular ischemia at the site of follicular rupture (i.e

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