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DSIP has been studied for various potential physiological roles, including: Stress response and adaptation Pain modulation Immune system regulation Antioxidant properties Effects on endocrine function DSIP has been investigated for potential applications in sleep disorders, pain management, and substance withdrawal syndromes

Although the pathology in CAE was mainly targeted to the corpus callosum where cuprizone-mediated white matter injury is focused, very prominent lymphocytic inflammation, demyelination and axonal injury were observed that closely resembled an active MS lesion