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In a 12-week, randomized, placebo-controlled trial in which 50,000 IUs (1,250 mcg) vitamin D was given weekly to 30 overweight women (age 1849) with PCOS and vitamin D deficiency, supplementation led to reduced unwanted hair growth and male hormone levels

Deleting VPS35 , a key retromer component, resulted in the mislocalization and degradation of both LYSET and GNPT

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Skin laxity is another concern with weight loss exceeding 15-20% of body weight