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Children under 18 years old: Only as professionally prescribed

In addition, it is important to rule out anemia caused by folate deficiency, as treating B12-deficient individuals with folate alone may exacerbate associated nerve damage

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Severe oxidative stress at the intestinal mucosa may lead to the loss of tight junction proteins through processes including the thiol oxidation, nitration, phosphorylation, and carbonylation of cytoskeletal proteins, tight junction proteins, and intracellular regulatory proteins 89