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Biopsy specimens from patients with minimal-change or IgA nephropathy and in UUO model showed CD4 + T lymphocytes infiltrate which contributed to the progression of kidney fibrosis [121]

Together with the fact that KA showed a dissociation constant 3-orders of magnitude higher than L-tyrosine, these findings support the existence of a significant intermediate binding site in TyrBm and explains the mechanism of mixed inhibition