This matters because antibody formation can indicate immune reactions and potentially reduce peptide effectiveness over time
As of the time of writing, 22 human UGT proteins can be distinguished: UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2A1, UGT2A2, UGT2A3, UGT2B4, UGT2B7, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT3A1, UGT3A2, and UGT8A1 (Mackenzie et al., 2008, Miners et al., 2006,Court et al., 2004, Patten, 2006, Sneitz et al., 2009)
556 Despite the efficacy of existing drugs, achieving a functional cure remains challenging
ROS can directly attack DNA, causing oxidative damage (Taniguchi et al., 2012), including base damage and single-strand breaks, which can cause DNA to mutate and change structurally (Roy, 2014)