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Discuss the potential benefits and risks

Using invasive sampling methods, such as bronchoalveolar lavage (BAL) or transtracheal aspiration (TTA), the LRT has been shown to host a low-biomass core microbiota dominated by Pasteurellaceae, Mycoplasmataceae, Flavobacteriaceae, Clostridiaceae, and Prevotellaceae, while archaea, viruses, and eukaryotic microbes are rarely reported (Table 1) 8,110,111,112

Better tissue health and metabolic state can support reproductive function

The stricter oversight introduced by the 2026 regulations aims to mitigate these risks, even if it means restricting access to certain therapies in the short term