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GCL can be inhibited by a buthionine sulphoximine quite specifically making it a useful tool in studying GSH metabolism, and useful in cancer chemotherapy (Martensson et al., 1989

Due to CR-induced immune system depletion and mutagenesis/genotoxic events (leading to occurrence and accumulation of a driver mutation and genome instability), the risks of oncogene activation and tumor suppressor depletion required for conversion to tumorinitiating cells over long periods could increase (60)

M.tb infection downregulates Sirt1 expression, which is crucial for negatively modulating inflammatory responses by inhibiting the activation of TAK1, MAPK and NF-B pathways and reducing IL-6 and TNF- levels

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