Authors concluded that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and subsequently DNA becomes methylated and inaccessible resulting in transcriptional silencing thus demonstrating interplay between histone reprogramming and promoter region methylation (Okino et al., 2007)
Kaschina E, Steckelings UM, Unger T (2018) Hypertension and the renin-angiotensin-aldosterone system
Specifically, PTX triggers the hierarchical activation of activating Transcription Factor 2 (ATF2), which upregulates Bim expression and promotes VDAC1-dependent Bax translocation and cytochrome c release 28
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