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MPC1-deficient C2C12 cells were generated by CRISPR and cultured as described (Oonthonpan, Rauckhorst, Gray, Boutron, & Taylor, 2019)

Why Methylated Vitamins Matter Methylated vitamins, like methylfolate and hydroxocobalamin are easily absorbed by the body, especially in people with genetic mutations like MTHFR, who struggle with processing non-methylated forms like folic acid and cyanocobalamin