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Zhang Q, Han L, Shi C, Jacamo R, Pan R, John MMC, Jeremy R, Kurtz S, Mu H, Ruvolo V, Ma H, Andreeff M , Mi Y, Tyner J, Leverson J, Letai A, Davis RE, Konopleva M

Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study

The chromophores mainly including trans-UCA(urocanic acid) in the stratum corneum and nucleotide bases in epidermal keratinocytes or immune cells (such as Langerhans cells) can absorb energy and induce the corresponding cellular damage pathway when exposed to UV light [109]

Reducing the levels of this signaling molecule with a drug reproduces some of these positive effects (Thevaranjan et al., 2017)