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Conversely, this same property makes result interpretation extrapolable to physiological biology trickier: in vivo, IGFBPs are not simple "plugs" but sophisticated regulators of IGF homeostasis

Authorship All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published