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Management strategies: Keep individual doses at 100 mcg or below Limit total daily GHRP-6 exposure to 300 mcg Prioritize the bedtime dose (cortisol is naturally lowest at night) Monitor for signs of cortisol excess: disrupted sleep, increased abdominal fat, mood changes Consider cycling 8 weeks on, 4 weeks off to prevent cumulative cortisol effects Prolactin elevation GHRP-6 can increase prolactin secretion, though the clinical significance varies by dose and individual sensitivity

Statistical analysis Descriptive statistics were calculated using mean and standard deviation (SD) or median and interquartile range (IQR) for continuous variables, as appropriate for the normality of the distribution, and using proportions for dichotomous and categorical variables

Subchronic cagrilintide treatment also increased Fos regulon expression in the Glu8.2 NTS Calcr/Prlh population in rats ( P adj = 0.026