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folate cycle) and adenosylcobalamin for methylmalonyl-CoA mutase (propionate metabolism)

Cyanocobalamin has many approved indications (many that lead to a deficiency of cyanocobalamin through an impairment of absorption of cyanocobalamin) including: Cyanocobalamin can be administered via intramuscular (IM) or subcutaneous (SC) routes

B12 is safe on its own, but a few conditions call for extra care, which is why a provider reviews your history before treatment: Leber's hereditary optic neuropathy, a rare inherited eye condition, where certain forms of B12 may be a concern for the optic nerve

However, the risk of bone fractures may be increased by supplements containing 25 mcg or more daily, according to some research