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Elevated DLAT expression was associated with resistance to HER-2-targeted therapy and sensitivity to immunotherapy (Sha R

A clinically defensible pathway therefore requires standardizing pre-analytics (cycle type, progesterone route, biopsy timing/site), clarifying the clinical question (timing correction vs endotype diagnosis), and integrating receptivity readouts with complementary layers when disruption is suspected, such as immune profiling and endometrial/uterine fluid proteomics/metabolomics, so that non-receptive is interpreted within a multi-dimensional endometrial endotype framework rather than as a single timing label

In one aspect, provided herein are otic formulations or compositions that are sterilized with stringent sterility requirements and are suitable for administration to the middle and/or inner ear