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In addition, overproduction of ROS has been shown to induce oxidative injury and cause atrophy of the urethral sphincter muscles, leading to impaired urethral closure (198)

ii) What are the definitive molecular determinants and microenvironmental cues that establish this context-dependence

Crucially, epigenetics acts as the interface between your genes and your environment, meaning that factors like stress, diet, sleep, and toxin exposure can alter gene expression without changing the underlying DNA code [31]

Individual variations and personalized approaches It's important to remember that individual responses to glutathione supplementation can vary