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Laboratory studies show modulation of genes involved in cell proliferation, immune response, and stress resistance

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Catalpol enhances the expression of brain-derived neurotrophic factor (BDNF) by upregulating the phosphorylation of cAMP response element-binding protein (CREB), improving the survival of -amyloid (A)-damaged SH-SY5Y neuroblastoma cells, and providing a theoretical basis for its neuroprotective effects in Alzheimers disease (Huang W