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doi: 10.1056/nejmoa1003466 24 BertrandAKostineMBarnetcheTTruchetetM-ESchaeverbekeT

they are complementary

It occupies a scientifically legitimate space between those extremes: a peptide with a plausible endogenous origin, a well-characterized set of molecular targets, and an unusually consistent preclinical record across diverse injury models and species

307 Therefore, the rational use of Wnt signalling pathway inhibitors is of great help to solve the clinical problems of tumour metastasis, recurrence and chemoresistance