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When cellular serine levels decrease, it activates one of the main effectors of the mTOR transcription factor, activating transcription factor 4 (ATF4), which then promotes the expression of serine synthesis pathway (SSP) enzymes to bring the serine level back to normal [71]

However, caution needs to be taken when increasing the intake of any of the lipid soluble vitamins

Nrf2 activators Sulforaphane, a bioactive isothiocyanate predominantly present in cruciferous vegetables, exerts its beneficial effects by activating the nuclear factor erythroid 2-related factor 2 pathway