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The main drivers for weight regain after significant WL include the persistence of a lower resting metabolic rate and the increased appetite, possibly mediated through long lasting increased orexigenic and decreased anorexigenic signals [2, 6]

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We take the K m of GST for GSH to be 5200 M, midway between the values 4500[21] and 5600[22], K m = 15 M for NAPQI, and V max = 72,000 M/hr