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Strikingly, estrogen deprivation was shown to be the principal mediator of impaired wound healing in the elderly population when a microarray study revealed that 78% of genes differentially expressed between wounds from young and aged men were estrogen-regulated, while only 3% were related to intrinsic aging (Lopez et al., 2016)

10.1016/j.brainres.2017.01.030 64

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The NG2 chondroitin sulfate proteoglycan: a multifunctional proteoglycan associated with immature cells